QWF
This tripeptide functions as a substance P antagonist (IC50 = 90 μM) and inhibits its binding to MRGPRX2. It blocks SP-induced, IgE-independent mast cell degranulation in vitro and suppresses compound 48/80-evoked MRGPRX2 activation and scratching behavior in murine models in vivo, supporting neuroimmunology and pruritus research.
Product Specifications
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Molecular Weight
697.78
Storage Conditions
-20°C
Notes
For research use only.
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