K41498

This potent small molecule is a highly selective CRF2 receptor antagonist, with Ki values of 0.66 nM and 0.62 nM for human CRF2α and CRF2β, respectively, and >600-fold selectivity over CRF1. It effectively inhibits sauvagine-stimulated cAMP accumulation in vitro and blocks urocortin-induced hypotension in rat models in vivo, making it a valuable tool for studying cardiovascular and stress-related disorders.