Huwentoxin-IV

This small molecule is a potent and selective inhibitor of neuronal voltage-gated sodium channels NaV1.7, NaV1.2, and NaV1.3. It acts by binding to neurotoxin site 4 in domain II, stabilizing a closed state. This mechanism makes it a valuable research tool for studying pain pathways and channelopathies in both cellular and animal models.