Recombinant SARS-CoV S-trimer Protein (C-6His)
Product Specifications
Background
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain
Abbreviation
Spike
Synonyms
SARS-CoV S glycoprotein; SARS-CoV S-trimer Protein; SARS-CoV Spike glycoprotein; SARS-CoV Sprotein
UniProt
P59594
Accession Number
P59594
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser14-Gln1190
Applications
ELISA
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Immobilized SARS-CoV S-trimer Protein-His (PKSV030289) at 5μg/ml (100 μl/well) can bind Human ACE-2- Fc (PKSR030492) . The ED50 of Recombinant Human ACE-2- Fc (PKSR030492) is 33. 26 ng/ml.
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
134.9 kDa
Observed Molecular Weight
170-220 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
SARS
Available Sizes
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