Acetyl-Calpastatin (184-210) (human)

This potent and selective calpain inhibitor exhibits high affinity for calpain I (Ki = 0.2 nM) and calpain II, while showing minimal activity against papain, trypsin, and cathepsin L. It is utilized in neuroscience research to modulate amyloid-β peptide production, specifically increasing the secretion of Aβ40, Aβ42, and the Aβ42/Aβ40 ratio in cellular models.