Cyclotraxin B
This small molecule is a potent and selective allosteric antagonist of the TrkB receptor, inhibiting BDNF signaling with an IC50 of 0.30 nM. It is a valuable research tool for studying BDNF/TrkB pathways in neuropathic pain and anxiety models, demonstrating efficacy in preventing BDNF-induced cold allodynia in vivo.
Product Specifications
Field of Research
Signal Transduction
Molecular Weight
1200.36
Storage Conditions
-20°C
Notes
For research use only.
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