AC 253

This small molecule AMY3 receptor antagonist inhibits adrenomedulin-stimulated cAMP production in vitro. It protects neuronal cultures from oligomeric Aβ-induced calcium dysregulation, aberrant PKA/MAPK/Akt signaling, and cell death, while also blocking Aβ's electrophysiological effects. Its research applications include studying amyloid toxicity mechanisms and potential neuroprotective strategies in Alzheimer's disease models.