Recombinant Human/Mouse/Rat GDF-8/Myostatin
Product Specifications
Background
Growth/differentiation factor 8 (Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues.
Abbreviation
GDF-8; Myostatin
Synonyms
GDF-8; Gdf8; Growth/differentiation factor 8; Mstn; Myostatin
UniProt
O14793
Accession Number
O14793
Expression System
HEK293 Cells
Tag
None
Sequence
Lys262-Ser375
Field of Research
Signal Transduction; Cell biology; Neuroscience; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
13.1 kDa
Observed Molecular Weight
12-15 kDa
Species
Human/Mouse/Rat
Available Sizes
Documents
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