Recombinant SARS-CoV-2 Papain-like Protease Protein (His Tag)
Product Specifications
Background
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
Synonyms
PL-PRO; PLpro; Papain-like Protease; Replicase polyprotein 1a; pp1a
Accession Number
YP_009725299.1
Expression System
E.coli
Tag
N-His
Sequence
Glu1564-Val1880
Applications
Enzyme
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Measured by its ability to cleave a fluorogenic peptide substrate, Arg-Leu-Arg-Gly-Gly-AMC (RLRGGAMC) . The Specific Activity is > 80pmols/min/μg
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/90z5zh
Product MSDS
https://789.bio/eb/uzPqP8
Calculated Molecular Weight
36.8 kDa
Species
SARS-CoV-2
Curated Selection
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