Recombinant Human ACE2 Protein (Fc Tag)

Product Specifications

Background

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

Abbreviation

ACE2

Synonyms

ACE-Related Carboxypeptidase; ACE2; ACEH; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Homolog; Metalloprotease MPROT15

UniProt

Q9BYF1

Accession Number

Q9BYF1

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Gln18-Ser740

Applications

ELISA

Field of Research

Cell biology; Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Immobilized Human ACE-2-Fc (Cat#PKSR030492) at 2μg/ml (100 μl/well) can bind 2019-nCoV S Protein RBD-SD1-mFc (Cat#PKSR030476) . The ED50 of Recombinant 2019-nCoV S Protein RBD-mFc (Cat#PKSR030476) is 15.5 ng/ml.