[Ala1,3,11,15]-Endothelin

This compound is a potent and selective endothelin receptor type B (ETB) agonist, exhibiting high affinity for the ETB receptor (IC50 = 0.33 nM) with over 6600-fold selectivity versus the ETA receptor. It is a valuable pharmacological tool for studying ETB-mediated vasodilation, cell proliferation, and endothelin system function in cardiovascular and pulmonary research models.