SAH-SOS1A

This small molecule inhibitor disrupts the KRas-SOS1 interaction by binding the KRas nucleotide pocket (Kd 106-176 nM), blocking nucleotide exchange and downstream ERK-MAPK signaling. It exhibits cell permeability and cytotoxicity in KRas-driven cancer models, supporting its use in oncology research for both in vitro and in vivo studies of Ras pathway dysregulation.