Stressin I

This small molecule is a potent and selective CRF1 receptor agonist (Ki = 1.5 nM for CRF1 vs. 224 nM for CRF2) . It elevates ACTH secretion in vitro and increases fecal pellet output in vivo following intraperitoneal injection, making it a valuable research tool for studying stress-related endocrine and gastrointestinal pathways.