R8-T198wt

This cell-permeable peptide inhibitor, derived from p27Kip1, selectively blocks Pim-1 kinase activity. It inhibits phosphorylation of targets like Bad, inducing G1 arrest and apoptosis in DU145 prostate cancer cells in vitro and in vivo, while sparing normal prostate epithelial cells. This makes it a valuable research tool for studying Pim-1-driven oncogenesis and therapeutic strategies.