Recombinant Cynomolgus PVRIG (C-6His)
Product Specifications
Background
PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Abbreviation
PVRIG
Synonyms
C7orf15; C7orf15MGC138295; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; transmembrane protein PVRIG
UniProt
A0A2K5WVV8
Accession Number
A0A2K5WVV8
Expression System
HEK293 Cells
Tag
C-His
Sequence
Thr41-Asp171
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/ccdud8
Product MSDS
https://789.bio/eb/n1Cmv9
Calculated Molecular Weight
14.5 kDa
Observed Molecular Weight
20-30 kDa
Species
Cynomolgus macaques
Available Sizes
Curated Selection
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