Recombinant Rhesus Macaque Angiotensin-Converting Enzyme 2/ACE-2 (C-Fc)
Product Specifications
Background
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Abbreviation
ACE2; ACE-2
Synonyms
ACE-Related Carboxypeptidase; ACE2; ACEH; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Homolog; Metalloprotease MPROT15
Accession Number
ACI04564.1
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Gln18-Val739
Applications
ELISA
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Immobilized 2019-nCoV S Protein RBD-SD1-mFc (Cat#PKSR030476) at 2μg/ml (100 μl/well) can bind Rhesus Macaque ACE-2-Fc (Cat#PKSQ050120) . The ED50 of Recombinant Rhesus Macaque ACE-2-His (Cat#PKSQ050120) is 96 ng/ml.
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
110.6 kDa
Observed Molecular Weight
120-140 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Rhesus Macaque
Available Sizes
Documents
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