Recombinant Cynomolgus FGL1 (C-6His)
Product Specifications
Background
Hepassocin, also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .
Abbreviation
FGL1
Synonyms
425O18-1; Angiopoietin-like protein 4; Angiopoietin-related protein 4; Angptl4; Farp; Fasting-induced adipose factor; Fiaf; HFARP; Hepatic fibrinogen/angiopoietin-related protein; Ng27; Secreted protein Bk89
UniProt
A0A2K5X990
Accession Number
A0A2K5X990
Expression System
HEK293 Cells
Tag
C-His
Sequence
Leu23-Ile312
Applications
BLI
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Loaded Cynomolgus LAG-3-Fc (Cat#PKSQ050015) on Protein A Biosensor, can bind Cynomolgus FGL1-His (Cat#PKSQ050095) with an affinity constant of 28.6nM as determined in BLI assay.
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
34.8 kDa
Observed Molecular Weight
35 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 10% Trehalose, 300mM NaCl, 50% Glycerol, 0.05% Tween 80, pH 8.5.
Species
Cynomolgus macaques
Available Sizes
Curated Selection
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