Recombinant Cavia porcellus CTLA-4/CD152 Protein (His Tag)
Product Specifications
Background
Cytotoxic Tlymphocyte 4 (CTLA-4, CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Abbreviation
CTLA-4; CD152
Synonyms
CD152; CTLA-4; CTLA4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4
UniProt
H0VUB1
Accession Number
H0VUB1
Expression System
P.Pichia
Tag
C-His
Sequence
Ala37-Asp161
Applications
Cell culture
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
50
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
16-35 kDa
Observed Molecular Weight
18-40 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Cavia porcellus
Available Sizes
Curated Selection
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