Recombinant Rhesus macaque IFNAR1 Protein (His Tag)

Product Specifications

Background

Interferon-alpha/beta receptor 1 (IFN-alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

Abbreviation

IFNAR1

Synonyms

AVP; Alpha-type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; I; IFN-alpha-REC; IFN-alpha/beta R1; IFN-alpha/beta receptor 1; beta-type antiviral protein; human interferon-alpha receptor (HuIFN-alpha-Rec) 10IFRC

UniProt

A0A7N9D7J0

Accession Number

XP_005548864.1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ala25-Lys437

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.