Recombinant Rhesus macaque IL-33/Interleukin-33 Protein (His Tag)

Product Specifications

Background

Interleukin-33 (IL-33) belongs to the IL-1 superfamily. IL33 is highly expressed in endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes, but almost undetectable in placenta. IL33 induces the production of T helper-2 (Th2) -associated cytokines. IL-33 is a cytokine that mediates its biological effects by binding to and signals through IL1RL1/ST2 and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines from polarized Th2 cells.

Abbreviation

IL-33; Interleukin-33

Synonyms

DVS; NF-HEV and IL- 1F; Interleukin-1 family member; C9orf; C9orf26; DVS27; Interleukin-1 family member 11; NF-HEV and IL- 1F11; NKHEV; IL33; Interleukin-33; IL-33; Interleukin 33; IL1F11; NFEHEV; NF-HEV

UniProt

F7DLG4

Accession Number

F7DLG4

Expression System

E.coli

Tag

N-His

Sequence

Ser112-Ile270

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.