Recombinant Cynomolgus CD40/TNFRSF5/CD40L Receptor Protein (Fc Tag)
Product Specifications
Background
CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction.
Abbreviation
CD40; TNFRSF5
Synonyms
B-Cell Surface Antigen CD40; Bp50; CD40; CD40L Receptor; CDw40; TNFRSF5; Tumor Necrosis Factor Receptor Superfamily member 5
UniProt
A0A2K5V585
Accession Number
XP_005569275.1
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Glu21-Arg193
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/impkrr
Product MSDS
https://789.bio/eb/TKO0KO
Calculated Molecular Weight
46.3 kDa
Observed Molecular Weight
48-70 kDa
Species
Cynomolgus macaques
Available Sizes
Curated Selection
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