Recombinant Cynomolgus PD-L2/B7-DC/CD273 Protein (Fc Tag)
Product Specifications
Background
Programmed Cell Death 1 Ligand 2 (PDCD1LG2) is a member of the BTN/MOG family. PDCD1LG2 contains one Ig-like C2-type domain and one Ig-like V-type domain. PDCD1LG2 is highly expressed in the heart, placenta, pancreas, lung and liver; it is weakly expressed in the spleen, lymph nodes, and thymus. PDCD1LG2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PDCD1LG2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Abbreviation
PD-L2; B7-DC; CD273
Synonyms
B7-DC; B7DC; Butyrophilin B7-DC; CD273; PD-1 Ligand 2; PD-L2; PDCD1 Ligand 2; PDCD1L2; PDCD1LG2; PDL2; Programmed Cell Death 1 Ligand 2; Programmed Death Ligand 2
UniProt
A4GW30
Accession Number
A4GW30
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Leu20-Pro219
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/ymam1r
Product MSDS
https://789.bio/eb/nffD80
Calculated Molecular Weight
49.5 kDa
Observed Molecular Weight
60-90 kDa
Species
Cynomolgus macaques
Available Sizes
Curated Selection
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