Recombinant Cynomolgus LAG-3/CD223 Protein (His Tag)
Product Specifications
Background
Lymphocyte Activating 3 (LAG3) belongs to immunoglobulin (Ig) superfamily, Macaca fascicularis LAG3 cDNA encodes 533 amino acids (aa) that include a 17 aa signal sequence, a 451 aa extracellular domain (ECD) with two Ig-like domains, a transmembrane region and a highly charged cytoplasmic region. LAG3' s main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function.
Abbreviation
LAG-3; CD223
Synonyms
CD223; LAG-3; LAG3; Lymphocyte Activating 3
Accession Number
XP_005570011.1
Expression System
HEK293 Cells
Tag
N-His
Sequence
Pro23-Leu450 (Pro74)
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/yq1vud
Product MSDS
https://789.bio/eb/DGOWPO
Calculated Molecular Weight
47.3 kDa
Observed Molecular Weight
55-65&140 kDa
Species
Cynomolgus macaques
Available Sizes
Curated Selection
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