Pomalidomide-C2-NH2 (hydrochloride)

Pomalidomide-C2-NH2 (Cereblon Ligand-Linker Conjugate 15) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

Product Specifications

CAS Number

[2305369-00-8]

Product Name Alternative

Cereblon Ligand-Linker Conjugates 15 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-17-hydrochloride.html

Purity

99.46

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCN)=O.[H]Cl

Molecular Formula

C15H17ClN4O4

Molecular Weight

352.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61 (2) :543-575.