Recombinant Mouse IL-36RA protein (His Tag)

Human Interleukin-36 Receptor Antagonist (IL-36RN) is a secreted protein which belongs to the Interleukin 1 cytokine family (IL-1 family) . IL-36RN is predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. IL-36RN is also detected in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. IL-36RN is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to Interleukin 1 family member 9 (IL1F9) . Dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders. Human and mouse IL-36RN share 90% sequence identity.

EBI; Interleukin; Il1f; Il1h; Il1hy; EBI3; EBV-induced gene 3 protein; Epstein-Barr virus-in duced gene 3 protein; IL-27-A; IL-27B; IL-30; Interleukin-27 subunit alpha; Interleukin-27 subunit beta; Interleukin-30; p28; Fil1d; Il1f5; Il1h3; Il1hy1; IL36RN

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.