Recombinant Mouse IL-36 alpha protein (His Tag)

Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

Interleukin-1 homolog; nterleukin-1 family member; Il1f; Il1h; IL-1F; IL-1H; FIL1 epsilon; FISP; IL-1 epsilon; IL-1F6; IL-1H1; Interleukin-1 epsilon; Interleukin-1 homolog 1; Interleukin-36 alpha; MDA-7 (Melanoma Differentiation-Associated gene 7 protein) ; nterleukin-1 family member 6; St16; Fil1e; Il1e; Il1f6; Il1h1; Il36a

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.