Recombinant Mouse TPBG/5T4 (C-6His)
Product Specifications
Background
Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG may function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. It expressed by all types of trophoblasts as early as 9 weeks of development. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
Abbreviation
TPBG;5T4
Synonyms
5T4 Protein;5T4AG Protein; Human; M6P1 Protein; WAIF1 Protein
UniProt
Q9Z0L0
Accession Number
Q9Z0L0
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser32-Ser361
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
36.6 kDa
Observed Molecular Weight
50-70 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Mouse
Available Sizes
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