Recombinant Mouse Alpha-1-antitrypsin 1-1/Serpin A1e (C-6His)
Product Specifications
Background
Alpha-1-antitrypsin 1-5 (SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.
Abbreviation
Serpin A1e
Synonyms
Alpha-1 protease inhibitor 5; Alpha-1-antitrypsin 1-5; Dom5; Serine protease inhibitor 1-5; Serine protease inhibitor A1e; Serpin A1e; Serpina1e; Spi1-5
UniProt
Q00898
Accession Number
Q00898
Expression System
HEK293 Cells
Tag
C-His
Sequence
Glu25-Lys413
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
44.5 kDa
Observed Molecular Weight
47-68 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Species
Mouse
Available Sizes
Curated Selection
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