Recombinant Mouse ST6GALNAC2 Protein (His Tag)
Product Specifications
Background
Alpha-N-acetylgalactosaminide alpha -2,6-sialyltransferase 2, is a type II membrane protein localized in the Golgi network and catalyzes 2,6-sialylation of the Tn antigen. Sialyl-Tn antigen is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis. It has been reported that disregulation of this gene is involved in the pathogenesis of IgA nephropathy, a common kidney disease that occurs when antibody IgA accumulates in kidneys (4) . The enzyme may also be used to synthesize a cancer vaccine.
Abbreviation
ST6GALNAC2
Synonyms
3-GalNAc alpha-2;6-sialyltransferase;6-sialyltransferase II; Gal-beta-1; GalNAc alpha-2; II; SIAT7-B; ST6GalNAc; ST6GalNAc II; Sialyltransferase 7B; Siat7; Siat7b
UniProt
P70277
Accession Number
P70277
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser28-Arg373
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
40.4 kDa
Observed Molecular Weight
45 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mMTris,150mMNaCl, pH7.5.
Species
Mouse
Available Sizes
Documents
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