Recombinant Mouse ST6GALNAC2 Protein (His Tag)

Product Specifications

Background

Alpha-N-acetylgalactosaminide alpha -2,6-sialyltransferase 2, is a type II membrane protein localized in the Golgi network and catalyzes 2,6-sialylation of the Tn antigen. Sialyl-Tn antigen is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis. It has been reported that disregulation of this gene is involved in the pathogenesis of IgA nephropathy, a common kidney disease that occurs when antibody IgA accumulates in kidneys (4) . The enzyme may also be used to synthesize a cancer vaccine.

Abbreviation

ST6GALNAC2

Synonyms

3-GalNAc alpha-2;6-sialyltransferase;6-sialyltransferase II; Gal-beta-1; GalNAc alpha-2; II; SIAT7-B; ST6GalNAc; ST6GalNAc II; Sialyltransferase 7B; Siat7; Siat7b

UniProt

P70277

Accession Number

P70277

Expression System

HEK293 Cells

Tag

C-His

Sequence

Ser28-Arg373

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

40.4 kDa

Observed Molecular Weight

45 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 50mMTris,150mMNaCl, pH7.5.

Species

Mouse

Available Sizes

Documents

Product Datasheet

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