Recombinant Mouse FAS/TNFRSF6 Protein (Fc Tag)
Product Specifications
Background
Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
Abbreviation
FAS; TNFRSF6
Synonyms
Apo-1 antigen; Apoptosis-mediating surface antigen FAS; CD95; FASLG receptor; Fas; TNFRSF6; Tumor necrosis factor receptor superfamily member 6
UniProt
P25446
Accession Number
P25446
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Gln22-Arg169
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/ppldy5
Product MSDS
https://789.bio/eb/58ifP4
Calculated Molecular Weight
43.7 kDa
Observed Molecular Weight
55 kDa
Species
Mouse
Available Sizes
Curated Selection
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