Recombinant Mouse IL1R1/CD121a Protein (His Tag)

Mouse Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family.This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA) . It is an important mediator involved in many cytokine induced immune and inflammatory responses. An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1α or IL1βbut not IL1ra, was identified. This Type I receptor complex appears to mediate all the known IL1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL1 signals. In addition to the membranebound form of IL1 RII, a naturallyoccurring soluble form of IL1 RII has been described. It has been suggested that the Type II receptor, either as the membranebound or as the soluble form, serves as a decoy for IL1 and inhibits IL1 action by blocking the binding of IL1 to the signaling Type I receptor complex.

D2S; Interleukin-1 receptor type; IL1-R; mIL-1R; CD121 antigen-like family member A; CD121a; CD121b; D2S1473; IL-1 RI; IL1R; Il1r-1; IL1-R1; IL-1R-1; IL-1R-alpha; IL-1RT1; IL-1RT-1; IL-iR; Interleukin-1 receptor alpha; Interleukin-1 receptor type 1; mIL-1R1; P80; Il-1r1; Il1ra; Il1r1; IL-1R type I; IL1R; Interleukin 1 receptor; interleukin 1 receptor type 1; mIL-1R1; type I

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.