Recombinant Mouse Interleukin-13/IL-13 Protein
Product Specifications
Background
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13Rα2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
Abbreviation
Interleukin-13; IL-13
Synonyms
BHR; Interleukin; T-Cell Activation Protein P; ALRH; BHR1; T-Cell Activation Protein P600; Interleukin-13; IL13; NC30; P600; Il-13
UniProt
P20109
Accession Number
P20109
Expression System
E.coli
Tag
C-His
Sequence
Pro22-Phe131
Applications
Cell culture
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
50 2.5 x 105 IU/mg.5
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/1otd8r
Product MSDS
https://789.bio/eb/XnvDqP
Calculated Molecular Weight
13.1 kDa
Observed Molecular Weight
11 kDa
Species
Mouse
Available Sizes
Curated Selection
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