Recombinant Mouse TRAIL R2/TNFRSF10B Protein (Fc Tag)

Product Specifications

Background

Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4) . TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.

Abbreviation

TRAIL R2; TNFRSF10B

Synonyms

CD262; DR5; Death Receptor 5; KILLER; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TNFRSF10B; TRAIL Receptor 2; TRAIL-R2; TRAILR2; TRICK2; Tumor Necrosis Factor Receptor Superfamily Member 10B; ZTNFR9

UniProt

Q9QZM4

Accession Number

Q9QZM4

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Asn53-Ser177

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.