Recombinant Mouse APCS/SAP Protein (His Tag)
Product Specifications
Background
Pentraxin 2 (PTX2), also known as Serum amyloid P (SAP), is a highly conserved, naturally circulating plasma protein and a soluble pattern recognition receptor of the innate immune system. The unique binding activities indicated that it may play an important role in the removal of damaged tissue. PTX2 belongs to the pentraxin family, is universally present in amyloid deposits. Mouse with targeted deletion of the PTX2 gene shows retarded and reduced induction of experimental reactive systemic (AA type) amyloidosis confirmed that it does indeed contribute to pathogenesis of amyloidosis and is a valid therapeutic target. In recent discovery, PTX2 can be used as a powerful antifibrotic agent to regulate certain monocyte differentiation states.
Abbreviation
APCS; SAP
Synonyms
9.5S alpha-1-glycoprotein; APCS; MGC88159; PTX2; PTX2serum amyloid P-component; SAP; SAP pentaxin-related; Serum amyloid P
Accession Number
P12246
Expression System
HEK293 Cells
Tag
C-His
Sequence
Gln21-Asp224
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
24.9 kDa
Observed Molecular Weight
28-32 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 50mM Imidazole, 5% Trehalose, 20% Glycerol, pH8.0.
Species
Mouse
Available Sizes
Curated Selection
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