Recombinant Mouse DR6/TNFRSF21 Protein (His Tag)
Product Specifications
Background
Tumor necrosis factor receptor superfamily member 21 (DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) . N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) .
Abbreviation
DR6; TNFRSF21
Synonyms
BM-018; CD358; DR6; Death receptor 6; Tnfrsf21; Tumor necrosis factor receptor superfamily member 21
Accession Number
Q9EPU5
Expression System
HEK293 Cells
Tag
C-Fc-His
Sequence
Gln42-His349
Field of Research
Cell biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/zl88ko
Product MSDS
https://789.bio/eb/4iDCKS
Calculated Molecular Weight
64.7 kDa
Observed Molecular Weight
75-120 KDa
Species
Mouse
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
