Recombinant Mouse 4-1BB/TNFRSF9 Protein (aa 24-187, Fc Tag)
Product Specifications
Background
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
Abbreviation
4-1BB; TNFRSF9
Synonyms
4-1BB; A930040I11Rik; AA408498; AI325004; CDw137; Cd137; ILA; Ly63; Secreted CD137 antigen; Tnfrsf9 ; Tumor necrosis factor receptor superfamily member 9
Accession Number
P20334
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Val24-Leu187
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
44.7 kDa
Observed Molecular Weight
60-70 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Species
Mouse
Available Sizes
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