Recombinant Mouse TNF-alpha/TNFA Protein

Tumor Necrosis Factor (TNF) is a member of the Tumor Necrosis Factor family. TNF exists as a homotrimer and interacts with SPPL2B. TNF is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes throught its effects on insulin resistance and fatty acid metabolism.

Cachectin; DIF; Membrane Form; TNF-Alpha; TNF-a; TNF-alpha; TNFSF2; TNFalpha; Tnf; Tnfa; Tnfsf1a; Tnfsf2; Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2

Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 2-8 pg/ml.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.