Recombinant Mouse TIMP2/TIMP-2 Protein (His Tag)
Product Specifications
Background
Mouse Metalloproteinase inhibitor 2 (TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs) . There are four mammalian members of the family; TIMP-1, TIMP-2, TIMP-3, and TIMP-4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.
Abbreviation
TIMP2; TIMP-2
Synonyms
CSC-21Ktissue inhibitor of metalloproteinase 2; TIMP metalloproteinase inhibitor 2; TIMP-2; Tissue inhibitor of metalloproteinase 2.; metalloproteinase inhibitor 2
UniProt
P25785
Accession Number
P25785
Expression System
HEK293 Cells
Tag
C-His
Sequence
Cys27-Pro220
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
22.5 kDa
Observed Molecular Weight
21 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Mouse
Available Sizes
Curated Selection
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