Recombinant Mouse SerpinD1/HCF2 Protein (His Tag)
Product Specifications
Background
SerpinD1, also known as heparin cofactor II (HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
Abbreviation
SerpinD1; HCF2
Synonyms
HC-II; Heparin cofactor 2; Heparin cofactor II; Protease inhibitor leuserpin-2; Serpin D1
UniProt
P49182
Accession Number
P49182
Expression System
HEK293 Cells
Tag
C-His
Sequence
Glu24-Ser478
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/iszqw9
Product MSDS
https://789.bio/eb/r5aDyP
Calculated Molecular Weight
53.1 kDa
Observed Molecular Weight
70-90 kDa
Species
Mouse
Available Sizes
Curated Selection
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