Recombinant Mouse Semaphorin-4C/SEMA4C Protein (Fc Tag)

Product Specifications

Background

Semaphorin-4C is a protein which belongs to the semaphorin family, contains 1 Ig-like C2-type domain, 1 PSI domain, 1 Sema domain. As cell surface receptor for PLXNB2, it plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. It required for normal brain development, axon guidance and cell migration, Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.

Abbreviation

Semaphorin-4C; SEMA4C

Synonyms

M-Sema F; S4c; Sema I; Sema4c; Semacl1; Semai; Semaphorin I; Semaphorin-4C; Semaphorin-C-like 1

UniProt

Q64151

Accession Number

Q64151

Expression System

HEK293 Cells

Tag

C-Fc

Sequence

Ala21-Gly664

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.