Recombinant Mouse PCSK9/NARC1 Protein (His Tag)
Product Specifications
Background
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis.PCSK9 also plays a role in neural development.
Abbreviation
PCSK9; NARC1
Synonyms
FH3; HCHOLA3; NARC-1; Narc1; Neural Apoptosis-Regulated Convertase 1; PC9; Pcsk9; Proprotein Convertase 9; Proprotein Convertase Subtilisin/Kexin Type 9; Subtilisin/Kexin-Like Protease PC9
UniProt
Q80W65
Accession Number
Q80W65
Expression System
HEK293 Cells
Tag
C-His
Sequence
Gln35-Gln155&Ser156-Gln694
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
14&58.2 kDa
Observed Molecular Weight
19&60 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
Species
Mouse
Available Sizes
Documents
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