Recombinant Mouse Interleukin-10/IL-10 Protein
Product Specifications
Background
Mouse Il10 is the prototypic member of the IL-10 cytokine family, including IL-10, IL-19, IL-20, IL-22 (IL-TIF), IL-24 and IL-26. Many viruses encode viral members of the IL-10 family, such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) .Its main function is inhibiting the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Although human and mouse IL-10 are 81% identical at the nucleotide and amino acid level, mouse IL-10 is species-specific and does not act on human cells. Interestingly, Human IL-10 is active on mouse cells.
Abbreviation
Interleukin-10; IL-10
Synonyms
Interleukin; IL-; CSIF; If2a; Il-10; IL10A; TGIF; Interleukin-10; IL10; Cytokine synthesis inhibitory factor; N/A; CSIF; If2a; Il-10
UniProt
P18893
Accession Number
P18893
Expression System
E.coli
Tag
C-His
Sequence
Ser19-Ser178
Applications
Cell culture
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method.
Purity
> 98 % as determined by reducing SDS-PAGE.
Bioactivity
50 1 x 106 IU/mg.6
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
19.7 kDa
Observed Molecular Weight
19 kDa
Species
Mouse
Available Sizes
Documents
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