Recombinant Mouse IL1RL1/ST2 Protein (Fc Tag)

ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2) . ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.

STE; DER; Fit; Protein T; Protein ST; Lymphocyte antigen; Interleukin-1 receptor-like; suppression of tumorigenicity; IL1RL; IL-1 R; IL-1RL; DER4; Fit-1; IL-1 R4; IL-1RL1; IL-33R; Interleukin-1 receptor-like 1; Lymphocyte antigen 84; Protein ST2; Protein T1; ST2L; ST2V; suppression of tumorigenicity 2; Ly84; St2; Ste2; Il1rl1

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.