Recombinant Mouse Granzyme B (G, H) /GZMB Protein (His Tag)
Product Specifications
Background
Granzyme B (GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Abbreviation
Granzyme B; GZMB
Synonyms
CCP1; CTLA-1; Ctla-1; Ctla1; Cytotoxic cell protease 1; Fragmentin-2; Granzyme B (G, H) ; Gzmb
UniProt
P04187
Accession Number
P04187
Expression System
HEK293 Cells
Tag
C-His
Sequence
Gly19-Ser247
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
26.5 kDa
Observed Molecular Weight
35 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Species
Mouse
Available Sizes
Documents
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