Recombinant Mouse CD32b/FCGR2B Protein (His Tag)

Product Specifications

Background

Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therapy for malignancies.

Abbreviation

CD32b; FCGR2B

Synonyms

CD32; Fc gamma receptor IIB; Fc-gamma RII; Fc-gamma-RIIB; FcRII; Fcgr2; Fcgr2b; IgG Fc receptor II beta; Low affinity immunoglobulin gamma Fc region receptor II; Ly-17; Lymphocyte antigen 17

UniProt

P08101

Accession Number

P08101

Expression System

HEK293 Cells

Tag

C-His

Sequence

Thr30-Pro210

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.