Recombinant Mouse Carbonic Anhydrase 4/CA4 Protein (aa 18-277, His Tag)
Product Specifications
Background
Carbonic anhydrase 4 (CA4) is an enzyme that belongs to the alpha-carbonic anhydrase family. CA4 consists of a signal peptide (residues1-17), an ectodomain (residues18-277) and a propeptide (residues278-305), which is removed in the mature form. it is predominantly expressed in the embryo. CA4 can catalyzes the reversible reaction of CO2+H2O=HCO3-+H+, and stimulates the sodium/bicarbonate transporter activity of SLC4A4. Studies have shown that this protein have a role in inherited renal abnormalities of bicarbonate transport. Alpha-carbonic anhydrase family participate in avariety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor. They show extensive diversity in tissue is attribution and in their sub cellular localization.
Abbreviation
Carbonic Anhydrase 4; CA4
Synonyms
CA-IV; CA4; CAIV; Car4; Carbonate dehydratase IV; EC4.2.1.1; RP17; carbonic anhydrase 4; carbonic anhydrase IVRP17; carbonic dehydratase IV; retinitis pigmentosa 17
UniProt
Q64444
Accession Number
Q64444
Expression System
HEK293 Cells
Tag
C-His
Sequence
Glu18-Ser277
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
30.5 kDa
Observed Molecular Weight
36 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Species
Mouse
Available Sizes
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