Recombinant Mouse ALK4/ACVR1B Protein (Fc Tag)
Product Specifications
Background
Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one protein kinase domain and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of nodal, GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.
Abbreviation
ALK4; ACVR1B
Synonyms
ACTR-IB; ACVR1B; ACVRLK4; ALK-4; ALK4; Activin Receptor Type IB; Activin Receptor Type-1B; Activin Receptor-Like Kinase 4; SKR2; Serine/Threonine-Protein Kinase Receptor R2
UniProt
Q61271
Accession Number
Q61271
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Leu32-Glu126
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/vqi5vd
Product MSDS
https://789.bio/eb/r5yXz9
Calculated Molecular Weight
37.7 kDa
Observed Molecular Weight
39-50 kDa
Species
Mouse
Available Sizes
Curated Selection
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