Recombinant Mouse CLEC10A/CD301 Protein (Fc Tag)
Product Specifications
Background
CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is a type II transmembrane glycoproteins and is expressed on macrophages and related cells of myeloid origins, particularly immature dendritic cells (DCs) . There are 2 homologues: MGL1 and MGL2 (CD301a and CD301b) in mice. MGL1/CD301a induces both the production and secretion of interleukin (IL) -10. MGL1/CD301a plays a protective role against colitis by effectively inducing IL-10 production by colonic lamina propria macrophages in response to invading commensal bacteria.
Synonyms
CD301a; M-ASGP-BP-1; Mgl; Mgl1
Accession Number
NP_001191181.1
Expression System
HEK293 Cells
Tag
N-hFc
Sequence
Gln 58-Ser 305
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 86 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/1dmqs4
Product MSDS
https://789.bio/eb/Si9OqH
Calculated Molecular Weight
56.7 kDa
Observed Molecular Weight
58 kDa
Species
Mouse
Curated Selection
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