Recombinant Mouse SRC Kinase/c-SRC Protein (His & GST Tag)
Product Specifications
Background
Proto-oncogene tyrosine-protein kinase SRC is a hydrophobic protein belonging to the SRC family kinase including nine members that is a family of non-receptor tyrosine kinases. SRC protein may exist in different forms: C-SRC and V-SRC. C-SRC is only activated under certain circumstances where it is required such as growth factor signaling, while V-SRC is a constitutively active as opposed to normal SRC (C-SRC) . Thus, V-SRC is an instructive example of an oncogene protein kinase whereas C-SRC is a proto-oncogene protein kinase. Inhibition of SRC with NR2A tyrosine phosphorylation mediated by PSD-95 may contribute to the lithium-induced downregulation of NMDA receptor function and provide neuroprotection against excitotoxicity.
Synonyms
AW259666; pp60c-src
Accession Number
NP_001020566.111
Expression System
Baculovirus-Insect Cells
Tag
N-His-GST
Sequence
Met 1-Leu 535
Applications
Enzyme
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
The specific activity was determined to be > 80 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate.
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
87.7 kDa
Observed Molecular Weight
80 kDa
Formulation
Supplied as sterile solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0
Species
Mouse
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